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Skin biopsies were taken from the periorbital (crow’s ft) space of the face at the start of the study and after 24 weeks of tretinoin utilization. At the top of the research, the researchers famous four dose-dependent changes in the skin of the tretinoin customers: an increase in epidermal thickness, a discount in melanin content material, stratum corneum compaction and an increase in granular layer thickness. 1. Topical Tretinoin Improves Photoaged Skin. A Double-blind Vehicle-controlled Study. 5. Topical Tretinoin For Treatment Of Photodamaged Skin. 6. Effects Of Tretinoin on Photodamaged Skin.